Enhanced Ca²⁺ influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy

2014
Written By Stellate Comms

Goonasekera SA, Davis J, Kwong JQ, Accornero F, Wei-LaPierre L, Sargent MA, Dirksen RT, Molkentin JD (2014) Human Molecular Genetics

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P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism
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Genetic deletion of the mitochondrial phosphate carrier desensitizes the mitochondrial permeability transition pore and causes cardiomyopathy